Protein Folding in Contact Map Space
نویسنده
چکیده
We represent a protein's structure by its contact map. Our aim is to identify the unknown fold of a known sequence by minimizing a (free) energy deened in the space of contact maps. To this end we developed an eecient method to search this space and to generate low energy maps that are also physical. We proved that the standard pairwise approximation to the free energy is unable to stabilize the native fold of a single protein against a set of carefully generated decoys.
منابع مشابه
Recovery of protein structure from contact maps.
BACKGROUND Prediction of a protein's structure from its amino acid sequence is a key issue in molecular biology. While dynamics, performed in the space of two-dimensional contact maps, eases the necessary conformational search, it may also lead to maps that do not correspond to any real three-dimensional structure. To remedy this, an efficient procedure is needed to reconstruct three-dimensiona...
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